Stern R S
Natl Cancer Inst Monogr. 1984 Dec;66:211-6.
Despite differences in study populations, methodologies, and levels of psoralen plus UV irradiation at 320-400 nm (PUVA), results from 4 prospective studies of patients treated with PUVA support the hypothesis that the risk of squamous cell carcinoma is increased with prolonged exposure. Tumors that develop after PUVA exposure behaved like skin tumors associated with sun exposure. In view of the latency for cancer in humans, continued prospective follow-up is required if we are to determine the ultimate carcinogenic risk of this type of therapy.
尽管在研究人群、方法以及320 - 400纳米补骨脂素加紫外线照射（PUVA）的剂量水平上存在差异，但4项关于接受PUVA治疗患者的前瞻性研究结果支持以下假设：随着暴露时间延长，鳞状细胞癌风险增加。PUVA暴露后发生的肿瘤表现类似于与阳光暴露相关的皮肤肿瘤。鉴于人类癌症存在潜伏期，如果我们要确定这类治疗的最终致癌风险，就需要持续进行前瞻性随访。
