Henseler T, Christophers E
Natl Cancer Inst Monogr. 1984 Dec;66:217-9.
From 1973 to 1981, the clinical data of 1,136 patients with psoriasis and another 1,210 with various skin tumors were accessioned with the aid of computerized data files. Skin tumors and psoriasis occurred in 48 patients. After psoralen plus 320-400 nm UV (PUVA) therapy for psoriasis was introduced in 1976, 381 patients with this disease were treated. Follow-up data revealed no change in the tumor incidence rate after this treatment began. Age-related calculations of the relative probabilities for the presence of skin cancer in patients with psoriasis after PUVA revealed a grossly normal pattern (which appeared to be unaffected by PUVA). We observed a skin tumor in 2 patients 5 years after PUVA therapy.
1973年至1981年期间，借助计算机化数据文件收集了1136例银屑病患者以及另外1210例患有各种皮肤肿瘤患者的临床数据。48例患者同时患有皮肤肿瘤和银屑病。1976年引入补骨脂素加320 - 400纳米紫外线（PUVA）治疗银屑病后，对381例该疾病患者进行了治疗。随访数据显示，开始这种治疗后肿瘤发病率没有变化。对接受PUVA治疗后的银屑病患者患皮肤癌的相对概率进行与年龄相关的计算，结果显示总体模式正常（似乎不受PUVA影响）。在PUVA治疗5年后，我们观察到2例患者出现了皮肤肿瘤。
