异丁苯丙酸多次治疗对佐剂诱导的多关节炎大鼠器官重量及血清谷丙转氨酶、碱性磷酸酶和尿素氮的影响。
Effects of multiple treatments of isoxicam on organ weights and serum SGPT, AP, and BUN in adjuvant-induced polyarthritic rats.
作者信息
DiPasquale G, Rassaert C, Welaj P, Gingold J, Schwartz E
出版信息
Res Commun Chem Pathol Pharmacol. 1978 Mar;19(3):529-32.
PMID:653106
Abstract
Isoxicam at 25 mg/kg/day x 28 days significantly inhibited the multiple alterations with the developing polyarthritis. In rats, this drug did not induce any changes in the relative liver weights or serum SGPT, AP, or BUN in polyarthritic rats. Isoxicam absorption was similar in normal and arthritic rats.
摘要
异恶酰草胺以25毫克/千克/天的剂量连续给药28天，可显著抑制正在发展的多关节炎的多种病变。在大鼠中，该药物对患多关节炎大鼠的肝脏相对重量、血清谷丙转氨酶、碱性磷酸酶或尿素氮没有任何影响。异恶酰草胺在正常大鼠和患关节炎大鼠中的吸收情况相似。
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