• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

异恶丙嗪（4-羟基-2-甲基-N-（5-甲基-3-异恶唑基-2H-1,2-苯并噻嗪-3-甲酰胺1,1-二氧化物）的抗炎特性。 （注：原文中“anti=inflammatory”拼写有误，正确应为“anti-inflammatory”）

The anti=inflammatory properties of isoxicam (4-hydroxy-2methyl-N-(5-methyl-3isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide).

作者信息

DiPasquale G, Rassaert C, Richter R, Welaj P, Gingold J, Singer R

出版信息

Agents Actions. 1975 Aug;5(3):256-63. doi: 10.1007/BF02026440.

DOI:10.1007/BF02026440
PMID:1236641
Abstract

Isoxicam is a potent, orally active, nonsteroidal anti-inflammarory drug with prolonged activtiy in experimentally induced inflammation in rats. Isoxicam is less ulcerogenic, acutely less toxic and, therefore, appears to have a therapeutic ratio superior to other standard agents to which it was compared.

摘要

异恶酰胺是一种强效的、口服有效的非甾体抗炎药，在实验诱导的大鼠炎症中具有持久活性。异恶酰胺致溃疡作用较小，急性毒性较低，因此，其治疗指数似乎优于与之比较的其他标准药物。

相似文献

1
The anti=inflammatory properties of isoxicam (4-hydroxy-2methyl-N-(5-methyl-3isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide).异恶丙嗪（4-羟基-2-甲基-N-（5-甲基-3-异恶唑基-2H-1,2-苯并噻嗪-3-甲酰胺1,1-二氧化物）的抗炎特性。 （注：原文中“anti=inflammatory”拼写有误，正确应为“anti-inflammatory”）
Agents Actions. 1975 Aug;5(3):256-63. doi: 10.1007/BF02026440.
2
Isoxicam and related 4-hydroxy-N-isoxazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides. Potent nonsteroidal antiinflammatory agents.
J Med Chem. 1982 Jan;25(1):12-8. doi: 10.1021/jm00343a003.
3
Effects of multiple treatments of isoxicam on organ weights and serum SGPT, AP, and BUN in adjuvant-induced polyarthritic rats.异丁苯丙酸多次治疗对佐剂诱导的多关节炎大鼠器官重量及血清谷丙转氨酶、碱性磷酸酶和尿素氮的影响。
Res Commun Chem Pathol Pharmacol. 1978 Mar;19(3):529-32.
4
Anti-inflammatory and pharmacokinetic properties of sudoxicam N-(2-thiazolyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide.
Biochem Pharmacol. 1972 Sep 1;21(17):2323-34. doi: 10.1016/0006-2952(72)90383-8.
5
Sudoxicam and related N-heterocyclic carboxamides of 4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide. Potent nonsteroidal antiinflammatory agents.舒多昔康及相关的4-羟基-2H-1,2-苯并噻嗪1,1-二氧化物的N-杂环羧酰胺。强效非甾体抗炎药。
J Med Chem. 1972 Aug;15(8):848-9. doi: 10.1021/jm00278a016.
6
Potent anti-inflammatory N-heterocyclic 3-carboxamides of 4-hydroxy-2-methyl-2H-1,2-benzothiazine 1,1-dioxide.
J Med Chem. 1973 May;16(5):493-6. doi: 10.1021/jm00263a017.
7
Anti-inflammatory activity of isoxicam in combination with aspirin or D-propoxyphene.异恶酰胺与阿司匹林或右丙氧芬联合使用的抗炎活性。
Agents Actions. 1976 Nov;6(6):748-54. doi: 10.1007/BF02026098.
8
Some new 1,2-benzothiazine derivatives with analgesic and anti-inflammatory activities.一些具有镇痛和抗炎活性的新型1,2-苯并噻嗪衍生物。
Arzneimittelforschung. 1996 Oct;46(10):966-71.
9
Comparative anti-inflammatory, analgesic, and antipyretic activities of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one and 5-chlorosalicylic acid in rats.7-氯-3,3a-二氢-2-甲基-2H,9H-异恶唑并-(3,2-b)(1,3)-苯并恶嗪-9-酮与5-氯水杨酸在大鼠体内的抗炎、镇痛和解热活性比较
J Pharm Sci. 1975 Aug;64(8):1321-4. doi: 10.1002/jps.2600640813.
10
Unusual coordinating behavior by three non-steroidal anti-inflammatory drugs from the oxicam family towards copper(II). Synthesis, X-ray structure for copper(II)-isoxicam, -meloxicam and -cinnoxicam-derivative complexes, and cytotoxic activity for a copper(II)-piroxicam complex.来自昔康家族的三种非甾体抗炎药对铜（II）的异常配位行为。铜（II）-异恶昔康、-美洛昔康和-肉桂昔康衍生物配合物的合成、X射线结构以及铜（II）-吡罗昔康配合物的细胞毒性活性。
J Inorg Biochem. 2007 Aug;101(8):1140-52. doi: 10.1016/j.jinorgbio.2007.04.015. Epub 2007 May 10.

引用本文的文献

1
Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists.NAP 同系物的设计、合成与生物学评价：外周作用向中枢作用的 μ 阿片受体拮抗剂的转变。
J Med Chem. 2022 Mar 24;65(6):5095-5112. doi: 10.1021/acs.jmedchem.2c00087. Epub 2022 Mar 7.
2
Comparison between plethysmometer and micrometer methods to measure acute paw oedema for screening anti-inflammatory activity in mice.用于筛选小鼠抗炎活性的体积描记法和千分尺法测量急性爪肿胀的比较。
Inflammopharmacology. 2004;12(1):89-94. doi: 10.1163/156856004773121400.
3
The effect of isoxicam-aspirin combinations on the polyurethane sponge implantation model in the rat.

本文引用的文献

1
ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF INDOMETHACIN, 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID.吲哚美辛（1-（对氯苯甲酰基）-5-甲氧基-2-甲基吲哚-3-乙酸）的抗炎和解热活性
J Pharmacol Exp Ther. 1963 Sep;141:369-76.
2
Effect of betamethasone 17-benzoate and 6 alpha, 9 alpha difluoroprednisolone 21-acetate 17-butyrate on the survival of adrenalectomized rats.17-苯甲酸倍他米松和6α,9α-二氟泼尼松龙21-醋酸酯17-丁酸酯对肾上腺切除大鼠存活的影响。
Steroids. 1970 Dec;16(6):693-701. doi: 10.1016/s0039-128x(70)80147-7.
3
Indomethacin-induced intestinal lesions in the rat.
异恶酰胺-阿司匹林组合对大鼠聚氨酯海绵植入模型的影响。
Br J Clin Pharmacol. 1986;22 Suppl 2(Suppl 2):125S-128S. doi: 10.1111/j.1365-2125.1986.tb02993.x.
4
The in vivo antiinflammatory effects of (E)-2,6-bis(1,1-dimethyl-ethyl)-4-[2-(5-methyl-1H-pyrazol-3-yl)ethenyl ] phenol (PD 127443) a novel dual inhibitor of 5-lipoxygenase and cyclooxygenase.（E）-2,6-双（1,1-二甲基乙基）-4-[2-（5-甲基-1H-吡唑-3-基）乙烯基]苯酚（PD 127443）的体内抗炎作用，5-脂氧合酶和环氧化酶的新型双重抑制剂。
Agents Actions. 1989 Jun;27(3-4):391-4. doi: 10.1007/BF01972831.
5
Metabolic disposition of the non-steroidal anti-inflammatory agent isoxicam in man.非甾体抗炎药异恶酰胺在人体内的代谢情况。
Eur J Drug Metab Pharmacokinet. 1992 Jan-Mar;17(1):21-7. doi: 10.1007/BF03189983.
6
Anti-inflammatory activity of isoxicam in combination with aspirin or D-propoxyphene.异恶酰胺与阿司匹林或右丙氧芬联合使用的抗炎活性。
Agents Actions. 1976 Nov;6(6):748-54. doi: 10.1007/BF02026098.
吲哚美辛诱导的大鼠肠道损伤
Toxicol Appl Pharmacol. 1970 Nov;17(3):615-24. doi: 10.1016/0041-008x(70)90036-0.
4
Nonsteroid anti-inflammatory agents.非甾体抗炎药。
Annu Rev Pharmacol. 1966;6:157-74. doi: 10.1146/annurev.pa.06.040166.001105.
5
Antiinflammatory 3,4-dihydro-2-alkyl-3-oxo-2H-1,2-benzothiazine-4-carboxamide 1,1-dioxides.
J Med Chem. 1971 Oct;14(10):973-7. doi: 10.1021/jm00292a022.
6
Factors influencing the development of indomethacin-induced intestinal ulcers in the rat.影响大鼠吲哚美辛诱导型肠道溃疡发生发展的因素。
Proc Soc Exp Biol Med. 1974 May;146(1):146-52. doi: 10.3181/00379727-146-38060.
7
The anti-inflammatory effects of 4-hydroxy-2-methyl-3-phenylcarbamoyl-2H-1,2-benzothiazine-1,1-dioxide (W7477).
Arch Int Pharmacodyn Ther. 1973 May;203(1):92-100.
8
Anti-inflammatory and pharmacokinetic properties of sudoxicam N-(2-thiazolyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide.
Biochem Pharmacol. 1972 Sep 1;21(17):2323-34. doi: 10.1016/0006-2952(72)90383-8.
9
Perspectives in nonsteroidal anti-inflammatory agents.
Angew Chem Int Ed Engl. 1972 Jun;11(6):460-72. doi: 10.1002/anie.197204601.
10
Comparative activities, tolerances and safety of nonsteroidal anti-inflammatory agents in rats.大鼠体内非甾体抗炎药的比较活性、耐受性及安全性
J Pharmacol Exp Ther. 1975 Jan;192(1):172-8.