Oligopeptides as models for Tyr/Glu sequences in the multichain co-polymer poly(Lys) poly(Tyr, Glu)-poly(DL-Ala).

The syntheses of a number of oligopeptides by classical means are reported. The peptides are designed as models for possible antigenic sequences among the Tyr/Glu sequences of a macromolecule widely used as antigen in immunogenetic studies, the multichain co-polymer, poly(Lys) poly(Tyr, Glu)-poly(DL Ala). Preliminary studies on the biological activity of the oligopeptides synthesized show that only peptides with the N-terminal sequence H-Tyr-Glu- do compete with the co-polymer in a double antibody radioimmune assay, whereas other sequences do not.