Sens M A, Hintz D S, Rutledge D S, Jenkins M Q, Sens D A
Pediatr Pathol. 1984;2(2):165-70. doi: 10.3109/15513818409025884.
The urine from patients with cystic fibrosis (CF) was screened for the presence of epithelial cells that could be serially propagated in vitro. The urine from two newborn infants with meconium ileus was an excellent source of epithelial cells, and over 400 cultures were initiated in each case. The urine of older CF patients hospitalized for pulmonary complications also yielded cells but in fewer numbers. No cells were obtained from older CF patients without pulmonary complications or from healthy volunteers. Hypoxia may be the factor stimulating cell exfoliation in the urine of sick CF patients and in a larger percentage of newborn infants.
对囊性纤维化（CF）患者的尿液进行筛查，以寻找可在体外连续传代培养的上皮细胞。两名患有胎粪性肠梗阻的新生儿的尿液是上皮细胞的优质来源，每种情况下均启动了400多次培养。因肺部并发症住院的年长CF患者的尿液也能培养出细胞，但数量较少。未出现肺部并发症的年长CF患者或健康志愿者的尿液中未获得细胞。缺氧可能是刺激患病CF患者及较大比例新生儿尿液中细胞脱落的因素。
