Voigt R, Thomas G
Pharmazie. 1983 Nov;38(11):736-9.
It is reported of the influence of adjuvants upon the pharmaceutical and biological availability of chlorpromazine hydrochloride from tablets. Sodium carboxymethyl cellulose, microcrystalline cellulose (Heweten 40) and potato starch have been used for tabletting. The adjuvants added act on the pharmaceutical availability, certain differences being due to a discriminate swelling behaviour. The differences observed in vitro exert no effect on the bioavailability of the drug in the rabbit. Thus, the tablets produced with the adjuvants mentioned have proved to be preparations of almost equivalent similar biopharmaceutical behaviour.
据报道了辅料对盐酸氯丙嗪片剂药物及生物利用度的影响。羧甲基纤维素钠、微晶纤维素（赫维特40）和马铃薯淀粉已用于压片。所添加的辅料对药物利用度有作用，某些差异归因于不同的溶胀行为。体外观察到的差异对家兔体内药物的生物利用度无影响。因此，用上述辅料制备的片剂已证明是生物药剂学行为几乎等同的制剂。
