Suranyi-Cadotte B, Quirion R, McQuade P, Nair N P, Schwartz G, Mosticyan S, Wood P L
Prog Neuropsychopharmacol Biol Psychiatry. 1984;8(4-6):737-41. doi: 10.1016/0278-5846(84)90049-6.
Reduced density of 3H-imipramine binding sites (Bmax) to platelets has been reported in depressed patients during an episode of illness. In the present study we assessed the usefulness of decreased Bmax of platelet 3H-imipramine binding as an indicator of the depressed state. We also investigated the effect of long-term treatment with imipramine on platelet 3H-imipramine binding. A comparison of platelet 3H-imipramine binding in 10 drug-free depressed patients and 8 normal volunteers revealed significantly lower mean Bmax values in depressed patients, whereas the affinity (Kd) of 3H-imipramine binding was identical in both groups. A longitudinal study of platelet 3H-imipramine binding in 10 depressed patients during and after imipramine treatment (125-200 mg/day) revealed consistently low Bmax values despite clinically meaningful improvement. However, Bmax values increased significantly following complete remission and remained elevated even after imipramine had been discontinued for 4 weeks. These findings suggest that decrease in the sensity of platelet 3H-imipramine binding sites in depressed patients is not likely to be a direct drug effect and that normalization of this variable may follow clinical remission.
据报道，在抑郁症患者发病期间，其血小板上3H-丙咪嗪结合位点（Bmax）的密度降低。在本研究中，我们评估了血小板3H-丙咪嗪结合Bmax降低作为抑郁状态指标的有用性。我们还研究了丙咪嗪长期治疗对血小板3H-丙咪嗪结合的影响。对10名未服用药物的抑郁症患者和8名正常志愿者的血小板3H-丙咪嗪结合情况进行比较，结果显示抑郁症患者的平均Bmax值显著较低，而两组中3H-丙咪嗪结合的亲和力（Kd）相同。对10名抑郁症患者在丙咪嗪治疗期间及治疗后（125 - 200毫克/天）的血小板3H-丙咪嗪结合进行的纵向研究表明，尽管临床症状有显著改善，但Bmax值一直较低。然而，在完全缓解后Bmax值显著升高，甚至在停用丙咪嗪4周后仍保持升高。这些发现表明，抑郁症患者血小板3H-丙咪嗪结合位点敏感性的降低不太可能是药物的直接作用，并且该变量的正常化可能伴随临床缓解。
