抑郁症患者和正常对照者血小板5-羟色胺摄取及3H-丙咪嗪结合的季节性模式之间的关系。

Relationship between seasonal patterns of platelet serotonin uptake and 3H-imipramine binding in depressed patients and normal controls.

Chicz-DeMet A, Reist C, DeMet E M

Department of Psychiatry and Human Behavior, University of California, Irvine.

Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(1):25-39. doi: 10.1016/0278-5846(91)90038-3.

Abstract

Significant seasonal variations were found in the velocity of serotonin (Vmax) uptake and the density of 3H-imipramine binding sites (Bmax) in blood platelets from normal controls. 2. Peak 3H-imipramine (3H-IMI) binding was found in February whereas peak serotonin (5HT) uptake was found in June and these measures were not correlated in paired comparisons. 3. Both Vmax and Bmax values of depressed patients deviated from the normal seasonal pattern with lower uptake and binding in the patient group. 4. A comparison of Vmax and Bmax deviations from the normal patterns of uptake and binding revealed a significant correlation between these measures such that patients with low Vmax values were the same as those with low Bmax values. 5. The results support previous claims that the 3H-IMI binding site may be closely associated with, or identical to, a 5HT transport carrier. 6. A significant correlation between uptake and binding further suggests that a common defect may be responsible for observed decreases in Vmax and Bmax values of depressed patients.

摘要

在正常对照组血小板中，发现血清素摄取速度（Vmax）和3H-丙咪嗪结合位点密度（Bmax）存在显著的季节性变化。2. 3H-丙咪嗪（3H-IMI）结合峰值出现在2月，而血清素（5HT）摄取峰值出现在6月，在配对比较中这些指标不相关。3. 抑郁症患者的Vmax和Bmax值均偏离正常季节性模式，患者组的摄取和结合较低。4. 比较Vmax和Bmax与正常摄取和结合模式的偏差，发现这些指标之间存在显著相关性，即Vmax值低的患者与Bmax值低的患者相同。5. 结果支持先前的说法，即3H-IMI结合位点可能与5HT转运载体密切相关或相同。6. 摄取与结合之间的显著相关性进一步表明，一个共同的缺陷可能是导致抑郁症患者观察到的Vmax和Bmax值降低的原因。