Scailteur V, Lauwerys R
Arch Toxicol. 1984 Dec;56(2):87-91. doi: 10.1007/BF00349077.
After in vivo administration of dimethylformamide (DMF) to male rats, about 50% of the dose is excreted in urine as N-hydroxymethyl-N-methylformamide (DMF-OH) and about 4% as N-methylformamide (NMF). NMF is not a product of DMF-OH biotransformation but is directly formed from DMF. Comparison of the acute toxicity of DMF, DMF-OH and NMF shows that NMF is more toxic than DMF-OH, which is itself more toxic than DMF. This study explains the different toxicity profile of DMF and NMF which until recently was believed to represent the main metabolite of DMF.
给雄性大鼠体内注射二甲基甲酰胺（DMF）后，约50%的剂量以N-羟甲基-N-甲基甲酰胺（DMF-OH）的形式经尿液排出，约4%以N-甲基甲酰胺（NMF）的形式排出。NMF不是DMF-OH生物转化的产物，而是由DMF直接形成的。DMF、DMF-OH和NMF的急性毒性比较表明，NMF的毒性比DMF-OH更大，而DMF-OH本身的毒性比DMF更大。这项研究解释了DMF和NMF不同的毒性特征，直到最近，NMF还被认为是DMF的主要代谢产物。
