Maury F, Moiraghi Ruggenini A, Grassi R
G Batteriol Virol Immunol. 1981 Jul-Dec;74(7-12):239-49.
The interactions between josamycin, other macrolides and lincomycin have been considered as far as the microbic resistance phenomenon is concerned, in relation to Staph. aureus strains. It has been possible to give rise to resistance to josamycin as well as to erythromycin even though the daily average increase is far lower for josamycin. Subinhibitory concentrations of josamycin have not provoked resistance in relation to other macrolides while this phenomenon has been observed as far as the use of erythromycin is concerned.
就微生物耐药现象而言，已对交沙霉素、其他大环内酯类药物和林可霉素之间与金黄色葡萄球菌菌株相关的相互作用进行了研究。已发现有可能产生对交沙霉素以及红霉素的耐药性，尽管交沙霉素的日均增加量要低得多。交沙霉素的亚抑菌浓度未引发对其他大环内酯类药物的耐药性，而在使用红霉素时则观察到了这种现象。
