Rinetti M, Cerutti R, Cisternino M, Colombi Zinelli L
Int J Clin Pharmacol Res. 1984;4(6):425-9.
The article discusses how and why drug responses are altered in elderly patients. It describes how the mutation of body composition and decay of physiological functions in the aged alters the pharmacokinetic parameters and consequently the drug responses. It also provides guidelines on which to base estimates of an accurate drug schedule.
本文讨论了老年患者药物反应如何以及为何会发生改变。它描述了老年人身体成分的变化和生理功能的衰退如何改变药代动力学参数，进而影响药物反应。此外，本文还提供了制定准确用药时间表的估算依据指南。
