Dobbs B R, Gazeley L R, Campbell A J, Edwards I R
Medical Research Council Toxicology Research Unit, University of Otago Medical School, Dunedin, New Zealand.
Eur J Clin Pharmacol. 1987;33(1):101-4. doi: 10.1007/BF00610390.
We have studied the pharmacokinetics of enoxacin in two groups of subjects, 10 young (18-45 years) and 10 elderly adults (greater than 65 years) after a single oral dose of enoxacin (600 mg). Enoxacin was absorbed rapidly, peak plasma concentrations being reached within two hours in both groups. However, the peak plasma concentration of enoxacin was significantly higher in the elderly than in the young adults. The area under the concentration-time curve extrapolated to infinity was also significantly greater in the elderly compared with the young subjects, and the apparent renal clearance was significantly less in the elderly than in the young adults. Consequently, the urinary elimination of unchanged enoxacin was significantly reduced in the elderly. The apparent volume of distribution in the elderly was significantly less than in the young adults. The elimination half-time of enoxacin was similar in the two groups.
我们研究了两组受试者单次口服600毫克依诺沙星后的药代动力学情况，一组为10名年轻人（18至45岁），另一组为10名老年人（大于65岁）。依诺沙星吸收迅速，两组均在两小时内达到血浆峰浓度。然而，老年人的依诺沙星血浆峰浓度显著高于年轻人。与年轻受试者相比，老年人浓度-时间曲线外推至无穷大时的曲线下面积也显著更大，且老年人的表观肾清除率显著低于年轻人。因此，老年人中未改变的依诺沙星经尿液排泄量显著减少。老年人的表观分布容积显著小于年轻人。两组中依诺沙星的消除半衰期相似。
