Gallery E D, Mitchell M D, Redman C W
J Hypertens. 1984 Apr;2(2):177-82. doi: 10.1097/00004872-198404000-00009.
The infusion of 500 ml of a volume expanding solution caused a significant fall in blood pressure for up to 72 h in 35 women with pregnancy-associated hypertension of varying grades of severity. The response to the infusion was not obviously related to the clinical severity of the underlying disorder, nor to the extent of plasma volume expansion produced. The plasma volume of oedematous women increased, while there was no significant change in non-oedematous women in response to the infusion. Changes in other measurements were similar in oedematous and non-oedematous women. There was no evidence for prostacyclin release into the circulation in response to the infusion as a mediator of the blood pressure response. Both 6-keto-prostaglandin F1 alpha levels and 13,14-dihydro-15-keto-prostaglandin F (PGFM) levels fell significantly, suggesting suppression of prostaglandin release by the infusion. The antihypertensive effect of volume expanders in pregnancy-associated hypertension is mediated by a factor other than simple volume expansion.
对35名患有不同严重程度妊娠相关性高血压的女性输注500毫升扩容溶液后，血压显著下降，持续长达72小时。输注反应与潜在疾病的临床严重程度以及所产生的血浆容量扩充程度均无明显关联。水肿女性的血浆容量增加，而未水肿女性在输注后血浆容量无显著变化。水肿和未水肿女性的其他测量指标变化相似。没有证据表明输注后有前列环素释放到循环中作为血压反应的介质。6-酮-前列腺素F1α水平和13,14-二氢-15-酮-前列腺素F（PGFM）水平均显著下降，提示输注抑制了前列腺素的释放。扩容剂在妊娠相关性高血压中的降压作用是由除单纯容量扩充之外的其他因素介导的。
