Knob M, Rosenmund H
Schweiz Med Wochenschr. 1978 May 27;108(21):788-91.
The inhibition test shows elevated creatine kinase MB (CK-MB) activity if the test volume is reduced. Hence, sera with considerably increased serum protein values may produce negative CK-MB results. What is involved here is an apparent blank phenomenon dependent on the serum proteins. This effect is not derived from the Inh-CK-M antibody but is directly connected with the CK-reagents, since analogous relationships are also shown with the conventional CK-method. In order to produce reliable inhibition test results, a reflectant blank versus test-volume and serum protein level must be taken into account.
抑制试验表明，如果测试体积减小，肌酸激酶MB（CK-MB）活性会升高。因此，血清蛋白值大幅升高的血清可能会产生CK-MB阴性结果。这里涉及到一种明显的依赖于血清蛋白的空白现象。这种效应并非源于Inh-CK-M抗体，而是与CK试剂直接相关，因为传统CK方法也显示出类似的关系。为了获得可靠的抑制试验结果，必须考虑与测试体积和血清蛋白水平相关的反射性空白。
