Cameron C M, Bester F J
Onderstepoort J Vet Res. 1984 Dec;51(4):263-7.
Extensive experiments in mice confirmed that the immunogenicity of a Corynebacterium pseudotuberculosis vaccine could not be significantly improved with the use of various adjuvants. Immunity against C. pseudotuberculosis likewise could not be enhanced by incorporating various immunostimulants into the vaccine or by the use of live vaccines. However, a combination of aluminium hydroxide gel and saponin as adjuvant did have a beneficial effect. This vaccine was tolerated better, and a smaller dose apparently protected sheep more effectively against intralymph node challenge than the currently available alum-precipitated vaccine.
在小鼠身上进行的大量实验证实，使用各种佐剂并不能显著提高伪结核棒状杆菌疫苗的免疫原性。同样，将各种免疫刺激剂加入疫苗中或使用活疫苗也无法增强对伪结核棒状杆菌的免疫力。然而，氢氧化铝凝胶和皂苷作为佐剂的组合确实具有有益效果。这种疫苗的耐受性更好，与目前可用的明矾沉淀疫苗相比，较小剂量的该疫苗显然能更有效地保护绵羊免受淋巴结内攻击。
