Brogden K A, Cutlip R C, Lehmkuhl H D
Am J Vet Res. 1984 Nov;45(11):2393-5.
Colostrum-deprived lambs were vaccinated IM with 10 mg (dry weight) of Corynebacterium pseudotuberculosis whole cells (WC) or cell walls (CW) and their immunity was challenged by IV injection of 3.1 X 10(4) colony-forming units of C pseudotuberculosis. Before challenge exposure, the logarithmic mean antibody titers were 2.0837 in lambs that were vaccinated with WC, 2.6858 in lambs that were vaccinated with CW, and 1.4214 in control lambs. Significant protection was demonstrated by fewer abscesses and organisms in the lungs of lambs vaccinated with WC or CW (P less than 0.05) than in control lambs. By the same criteria, more protection was provided to lambs vaccinated with CW than to lambs vaccinated with WC.
初乳缺乏的羔羊通过肌肉注射10毫克（干重）的假结核棒状杆菌全细胞（WC）或细胞壁（CW）进行疫苗接种，然后通过静脉注射3.1×10⁴个假结核棒状杆菌菌落形成单位来激发其免疫力。在激发暴露前，接种WC的羔羊对数平均抗体滴度为2.0837，接种CW的羔羊为2.6858，对照羔羊为1.4214。与对照羔羊相比，接种WC或CW的羔羊肺部脓肿和细菌数量更少，显示出显著的保护作用（P<0.05）。按照相同标准，接种CW的羔羊比接种WC的羔羊获得了更多的保护。
