Płaźnik A
Pol J Pharmacol Pharm. 1984 Sep-Oct;36(5):541-54.
The effects of microinjections of serotonin (5HT) and noradrenaline (NA) into the limbic structures of the rat brain on the open field behavior and acquisition and retention of a step-down passive avoidance, were examined. Bilateral injections of NA and 5HT into the dorsal hippocampus (DH) produced opposite effects in the open field test, of excitatory and inhibitor nature, respectively. Intrahippocampal injections of 5HT slightly attenuated passive avoidance acquisition and significantly impaired its retention. Bilateral microinjections of NA and 5HT into the basomedial amygdala (BMA) inhibited locomotor activity and exploration in the open field test. In a dose of 40 micrograms, NA and 5HT significantly attenuated also the performance of an avoidance retention, examined 24 h after training. Bilateral injection of NA and 5HT into nucleus accumbens septi (NAS) inhibited 5 min later the locomotor activity and exploration in the open field test. The monoamines administered in various doses into the NAS before training did not consistently influence the rate of acquisition and retention of a passive avoidance reaction. The data are discussed in terms of an involvement of monoaminergic innervation of limbic structures of the brain in the organization of animal behavior.
研究了向大鼠脑海马结构微量注射5-羟色胺（5HT）和去甲肾上腺素（NA）对旷场行为以及一步下被动回避反应的获得与保持的影响。向背侧海马（DH）双侧注射NA和5HT在旷场试验中分别产生了兴奋和抑制性质的相反作用。海马内注射5HT略微减弱了被动回避反应的获得，并显著损害了其保持。向基底内侧杏仁核（BMA）双侧微量注射NA和5HT在旷场试验中抑制了运动活动和探索行为。在剂量为40微克时，NA和5HT在训练后24小时检测时也显著减弱了回避保持的表现。向伏隔核（NAS）双侧注射NA和5HT在5分钟后抑制了旷场试验中的运动活动和探索行为。在训练前向NAS注射不同剂量的单胺对被动回避反应的获得和保持速率没有一致的影响。从脑海马结构单胺能神经支配参与动物行为组织的角度对这些数据进行了讨论。
