Efficacies of whole blood and plasma cross circulation on galactosamine induced hepatic failure rats.

Galactosamine induced hepatic failure rats were treated by whole blood and plasma cross circulation. While no significant improvement in survival rate was achieved by means of these 2 procedures, oxygen consumption in state 3 and ATP synthesis of mitochondrial function were significantly improved as compared to the sham circulation groups. Maintenance of mitochondrial functions as by extracorporeal perfusion techniques may be advantageous in acute hepatic failure.