Kauppinen K, Gröhn Y
Acta Vet Scand. 1984;25(4):467-79. doi: 10.1186/BF03546915.
Four different treatments of bovine ketosis, using 3 different pharmaceutical preparations, were monitored. The main antiketogenic and glucogenic ingredients of the preparations were as follows: invert sugar (Metabol), prednisolone and dexamethasone (Predasen), the former preparations combined (Metabol & Predasen) and propylene glycol and dexamethasone (Dexaprol). Blood samples were drained from the ketotic cows prior to the treatment. The animals were sampled again 2 and 7 days after the first sampling. The whole blood concentrations of acetoacetate (AA concn), β-hydroxybutyrate (BHB concn) and glucose (glue concn) were determined. The measures of the antiketogenic and glucogenic efficacy of the various treatments applied were their ability to reduce the AA concn and BHB concn and to elevate the gluc concn. Invert sugar (Metabol) alone had no antiketogenic efficacy, although in some cases it led to a subjective clinical improvement as reported by the owners of the animals. Invert sugar and glucocorticoids (Metabol & Predasen) dexamethasone and prednisolone (Predasen) and dexamethason plus propylene glycol (Dexaprol) were equally effective in bringing the AA, BHB and glue concns to normal range. The mean glue concn of the cows treated with Dexaprol was higher than that of the cows in the other treatment groups at 2 days (P < 0.01). No other differences between the 3 antiketogenic treatments could be shown.
对使用3种不同药物制剂的4种不同牛酮血症治疗方法进行了监测。这些制剂的主要抗酮生成和生糖成分如下：转化糖（Metabol）、泼尼松龙和地塞米松（Predasen）、前两种制剂联合使用（Metabol & Predasen）以及丙二醇和地塞米松（Dexaprol）。在治疗前从患酮血症的奶牛身上采集血样。在首次采样后的第2天和第7天再次对这些动物进行采样。测定了全血中乙酰乙酸（AA浓度）、β-羟基丁酸（BHB浓度）和葡萄糖（葡萄糖浓度）的浓度。所应用的各种治疗方法的抗酮生成和生糖功效的衡量标准是它们降低AA浓度和BHB浓度以及提高葡萄糖浓度的能力。单独使用转化糖（Metabol）没有抗酮生成功效，尽管在某些情况下，动物主人报告说它带来了主观的临床改善。转化糖与糖皮质激素联合使用（Metabol & Predasen）、地塞米松和泼尼松龙（Predasen）以及地塞米松加丙二醇（Dexaprol）在使AA、BHB和葡萄糖浓度恢复到正常范围方面同样有效。在第2天，用Dexaprol治疗的奶牛的平均葡萄糖浓度高于其他治疗组的奶牛（P < 0.01）。在3种抗酮生成治疗方法之间未显示出其他差异。
