色胺衍生物与吡哆醛缩合产物的合成及药理性质
Synthesis and pharmacological properties of the products of condensation of tryptamine derivatives with pyridoxal.
作者信息
Misztal S, Boksa J, Grabowska M, Chojnacka-Wójcik E, Tatarczyńska E
出版信息
Pol J Pharmacol Pharm. 1984 Nov-Dec;36(6):689-96.
PMID:6535159
Abstract
Four new derivatives of 1,2,3,4-tetrahydro-beta-carboline 2a--d were synthetized with the pyridoxal moiety in position 1; there were also obtained four Schiff bases 1a--d which are intermediate products in this synthesis. Schiff bases 1a--d revealed a sedative and analgesic action, and compound 1b also had potential antidepressive properties. The derivatives of tetrahydro-beta-carboline 2a--d were inactive in the carried out tests.
摘要
合成了4种1,2,3,4-四氢-β-咔啉2a-d的新衍生物，其1位带有吡哆醛部分；还得到了4种席夫碱1a-d，它们是该合成中的中间产物。席夫碱1a-d显示出镇静和镇痛作用，化合物1b还具有潜在的抗抑郁特性。四氢-β-咔啉2a-d的衍生物在进行的测试中无活性。
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