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[口腔底部癌放射治疗的结果与适应症]

[Results and indications of radiotherapy in the treatment of carcinoma of the mouth floor].

作者信息

Volterrani F, Tana S, Trenti N, Gramaglia A

出版信息

Radiol Med. 1984 Jul-Aug;70(7-8):528-35.

PMID:6535172
Abstract

175 carcinomas of the floor of the mouth were treated by radiotherapy in the years 1971-81: 47 T1 (26.9%) 87 T2 (49.7%) 19 T3 (10.8%) 22 T4 (12.6%). According to local extension the primary was treated by curietherapy in 92 patients (52.6%), external radiotherapy plus curietherapy boost in 8 (4.6%), radiosurgical combinations in 25 (14.3%) and external radiotherapy alone in 50 (28.5%). 131 patients were initially N0 (74.9%) 23 N1 (13.1%) 21 N2-3 (12.0%). The treatment on the nodal areas was: wait and see in 84 patients (48.0%) surgery in 39 (22.3%) radiosurgical combinations in 21 (12.0%) external radiotherapy alone in 31 (17.7%). Relapses free survival at 2 and 5 years was respectively 52.5% and 44.1%. Local control was obtained for 37/41 T1 cases (90.2%) 58/71 T2 (81.7%) 9/25 T3-T4 (36.0%). 37/137 patients with adequate follow-up (greater than or equal to 1 year) experienced some radionecrotic complications (27.0%). The overall incidence of the second tumors was 7.3% (10 cases).

摘要

1971年至1981年间,175例口腔底部癌接受了放射治疗:47例为T1期(26.9%),87例为T2期(49.7%),19例为T3期(10.8%),22例为T4期(12.6%)。根据局部扩展情况,92例患者(52.6%)的原发灶采用近距离治疗,8例(4.6%)采用外照射放疗加近距离治疗强化,25例(14.3%)采用放射外科联合治疗,50例(28.5%)仅采用外照射放疗。131例患者最初为N0期(74.9%),23例为N1期(13.1%),21例为N2 - 3期(12.0%)。对淋巴结区域的治疗方式为:84例患者(48.0%)采取观察等待,39例(22.3%)采取手术,21例(12.0%)采取放射外科联合治疗,31例(17.7%)仅采用外照射放疗。2年和5年的无复发生存率分别为52.5%和44.1%。41例T1期病例中有37例(90.2%)实现局部控制,71例T2期病例中有58例(81.7%),25例T3 - T4期病例中有9例(36.0%)。137例接受充分随访(大于或等于1年)的患者中有37例(27.0%)出现了一些放射性坏死并发症。第二肿瘤的总体发生率为7.3%(10例)。

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