Volterrani F, Tana S, Trenti N, Gramaglia A
Radiol Med. 1984 Jul-Aug;70(7-8):528-35.
175 carcinomas of the floor of the mouth were treated by radiotherapy in the years 1971-81: 47 T1 (26.9%) 87 T2 (49.7%) 19 T3 (10.8%) 22 T4 (12.6%). According to local extension the primary was treated by curietherapy in 92 patients (52.6%), external radiotherapy plus curietherapy boost in 8 (4.6%), radiosurgical combinations in 25 (14.3%) and external radiotherapy alone in 50 (28.5%). 131 patients were initially N0 (74.9%) 23 N1 (13.1%) 21 N2-3 (12.0%). The treatment on the nodal areas was: wait and see in 84 patients (48.0%) surgery in 39 (22.3%) radiosurgical combinations in 21 (12.0%) external radiotherapy alone in 31 (17.7%). Relapses free survival at 2 and 5 years was respectively 52.5% and 44.1%. Local control was obtained for 37/41 T1 cases (90.2%) 58/71 T2 (81.7%) 9/25 T3-T4 (36.0%). 37/137 patients with adequate follow-up (greater than or equal to 1 year) experienced some radionecrotic complications (27.0%). The overall incidence of the second tumors was 7.3% (10 cases).
1971年至1981年间，175例口腔底部癌接受了放射治疗：47例为T1期（26.9%），87例为T2期（49.7%），19例为T3期（10.8%），22例为T4期（12.6%）。根据局部扩展情况，92例患者（52.6%）的原发灶采用近距离治疗，8例（4.6%）采用外照射放疗加近距离治疗强化，25例（14.3%）采用放射外科联合治疗，50例（28.5%）仅采用外照射放疗。131例患者最初为N0期（74.9%），23例为N1期（13.1%），21例为N2 - 3期（12.0%）。对淋巴结区域的治疗方式为：84例患者（48.0%）采取观察等待，39例（22.3%）采取手术，21例（12.0%）采取放射外科联合治疗，31例（17.7%）仅采用外照射放疗。2年和5年的无复发生存率分别为52.5%和44.1%。41例T1期病例中有37例（90.2%）实现局部控制，71例T2期病例中有58例（81.7%），25例T3 - T4期病例中有9例（36.0%）。137例接受充分随访（大于或等于1年）的患者中有37例（27.0%）出现了一些放射性坏死并发症。第二肿瘤的总体发生率为7.3%（10例）。
