Kami K, Mitsui T
Tokai J Exp Clin Med. 1984 Mar;9(1):53-67.
An electron microscopic study has been performed on placentas from women with maternal diabetes. None of the patients had suffered from any of the hypertensive complications of pregnancy (White's class A). Most villous trophoblasts were morphologically normal and showed features suggestive of normal or increased synthetic transport and excretory activity. These cells appeared to be far more "active" than their counterparts in normal term placentas in that many contained Golgi bodies that were often associated with membrane-bound osmiophilic vesicles. Focal thickening of the trophoblastic basement membrane was seen. The endothelial capillaries contained an excessive number of microfibrillae and micropinocytotic vesicles and appeared unduly immature. Very abundant osmiophilic granules were seen in many villous components, such as syncytiotrophoblasts, stromal fetal endothelial cells, pericytes, Hofbauer cells and fibroblasts. These may have been concerned in the cross-transportation of materials between the maternal intervillous space and the fetal capillaries, rather than the incorporation of substances within them. These morphological changes did not show, however, any specific, constant or uniform pattern of abnormality attributable maternal diabetes.
对患有妊娠糖尿病女性的胎盘进行了电子显微镜研究。所有患者均未患有任何妊娠高血压并发症（怀特A类）。大多数绒毛滋养层细胞形态正常，显示出正常或增强的合成、运输和排泄活动特征。这些细胞似乎比足月正常胎盘的对应细胞“活跃”得多，因为许多细胞含有高尔基体，这些高尔基体通常与膜结合的嗜锇性小泡相关。可见滋养层基底膜局灶性增厚。内皮毛细血管含有过多的微原纤维和微饮小泡，显得异常不成熟。在许多绒毛成分中，如合体滋养层细胞、间质胎儿内皮细胞、周细胞、霍夫鲍尔细胞和成纤维细胞中，可见非常丰富的嗜锇性颗粒。这些颗粒可能与母血绒毛间隙和胎儿毛细血管之间的物质交叉运输有关，而不是与物质在其中的掺入有关。然而，这些形态学变化并未显示出任何可归因于妊娠糖尿病的特定、恒定或统一的异常模式。
