Hoshino Y, Ohno Y, Murata S, Yokoyama F, Kaneko M, Kumashiro H
Folia Psychiatr Neurol Jpn. 1984;38(4):445-9. doi: 10.1111/j.1440-1819.1984.tb00793.x.
A dexamethasone suppression test (DST) was carried out on autistic and other handicapped children to investigate the function of the hypothalamo-pituitary adrenal axis (HPA-axis). The subjects were 19 autistic children consisting of 11 relatively well-developed and eight poorly-developed children. The control groups were 26 normal volunteers, 19 patients with schizophrenia and 15 children with mental retardation (MR) or minimal brain dysfunction (MBD). The DST procedures followed the Carroll method. As a result, all of the normal volunteers and 19 schizophrenic patients showed normal response (suppressor). Nine of the 11 well-developed autistic children exhibited suppressor, while all of the poorly-developed children showed an abnormal response (non-suppressor). Nine of the 10 children with MR and all of the five children with MBD were suppressor. These results suggest that there might be a dysfunction in the HPA-axis of the poorly-developed autistic children.
对自闭症及其他残疾儿童进行了地塞米松抑制试验（DST），以研究下丘脑 - 垂体 - 肾上腺轴（HPA轴）的功能。研究对象为19名自闭症儿童，其中11名发育相对良好，8名发育不良。对照组包括26名正常志愿者、19名精神分裂症患者以及15名智力发育迟缓（MR）或轻度脑功能障碍（MBD）的儿童。DST程序采用卡罗尔方法。结果显示，所有正常志愿者和19名精神分裂症患者反应正常（抑制型）。11名发育良好的自闭症儿童中有9名表现为抑制型，而所有发育不良的儿童均表现出异常反应（非抑制型）。10名患有MR的儿童中有9名以及所有5名患有MBD的儿童均为抑制型。这些结果表明，发育不良的自闭症儿童的HPA轴可能存在功能障碍。
