Nir I, Meir D, Zilber N, Knobler H, Hadjez J, Lerner Y
Eitanim Psychiatric Hospital, Jerusalem, Israel.
J Autism Dev Disord. 1995 Dec;25(6):641-54. doi: 10.1007/BF02178193.
An abnormal circadian pattern of melatonin was found in a group of young adults with an extreme autism syndrome. Although not out of phase, the serum melatonin levels differed from normal in amplitude and mesor. Marginal changes in diurnal rhythms of serum TSH and possibly prolactin were also recorded. Subjects with seizures tended to have an abnormal pattern of melatonin correlated with EEG changes. In others, a parallel was evidenced between thyroid function and impairment in verbal communication. There appears to be a tendency for various types of neuroendocrinological abnormalities in autistics, and melatonin, as well as possibly TSH and perhaps prolactin, could serve as biochemical variables of the biological parameters of the disease.
在一组患有极端自闭症综合征的年轻成年人中发现了褪黑素的昼夜节律异常。虽然相位未改变，但血清褪黑素水平在振幅和中值方面与正常情况不同。还记录到血清促甲状腺激素（TSH）以及可能的催乳素的昼夜节律有轻微变化。患有癫痫的受试者往往有与脑电图变化相关的褪黑素异常模式。在其他方面，甲状腺功能与言语交流障碍之间存在平行关系。自闭症患者似乎有出现各种类型神经内分泌异常的倾向，褪黑素以及可能的TSH和或许还有催乳素可作为该疾病生物学参数的生化变量。
