Berlin G, Brodin B, Hilden J O, Mårtensson J
J Toxicol Clin Toxicol. 1984;22(6):537-48. doi: 10.3109/15563658408992583.
A case of massive dapsone poisoning (15 g) in a 26 year old man is reported. The patient exhibited high plasma dapsone concentration, marked methemoglobinemia, and signs of hemolysis. He recovered completely after intensive treatment with methylene blue, activated charcoal, forced diuresis, and plasma exchange. In order to avoid overdosage of methylene blue it is concluded that this substance should be given by continuous intravenous infusion in cases with severe methemoglobinemia. This way of administration caused a steady decrease in the methemoglobin concentration compared to intermittent administration. Plasma exchange was of minor benefit, probably due to the large distribution volume of dapsone.
报告了一例26岁男性服用大剂量氨苯砜（15克）中毒的病例。该患者血浆氨苯砜浓度高，有明显的高铁血红蛋白血症和溶血迹象。经亚甲蓝、活性炭、强制利尿和血浆置换强化治疗后，他完全康复。为避免亚甲蓝过量，得出结论：对于严重高铁血红蛋白血症患者，该物质应以持续静脉输注的方式给药。与间歇性给药相比，这种给药方式使高铁血红蛋白浓度稳步下降。血浆置换的益处不大，可能是由于氨苯砜的分布容积大。
