亚甲蓝输注治疗小儿患者严重氨苯砜诱导的高铁血红蛋白血症
Methylene Blue Infusion to Treat Severe Dapsone-Induced Methemoglobinemia in a Pediatric Patient.
作者信息
Alyahya Bader, Alalshaikh Abdulaziz, Sabbahi Ghofran, Alnowiser Mosaed, Al-Mohawes Mohammed
机构信息
Emergency Medicine, King Saud University, Riyadh, SAU.
Pediatric Infectious Diseases, King Abdulaziz University Hospital, Jeddah, SAU.
出版信息
Cureus. 2021 Oct 18;13(10):e18853. doi: 10.7759/cureus.18853. eCollection 2021 Oct.
Abstract
Dapsone overdose is a well-known potent cause of methemoglobinemia and hemolytic anemia. We discuss a case of a two-year-old male who developed severe persistent methemoglobinemia treated with multiple doses of methylene blue (MB), multidose activated charcoal, and vitamin C. Methylene blue infusion (rather than bolus dosing) aided in controlling this patient's methemoglobin (MetHb) levels and symptoms and may reduce the total needed dose.
摘要
氨苯砜过量是已知的导致高铁血红蛋白血症和溶血性贫血的强效原因。我们讨论了一例两岁男性病例，该患者出现严重持续性高铁血红蛋白血症，接受了多剂量亚甲蓝（MB）、多剂量活性炭和维生素C治疗。亚甲蓝输注（而非推注给药）有助于控制该患者的高铁血红蛋白（MetHb）水平和症状，并可能减少所需的总剂量。
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