Loew F, Pertuiset B, Chaumier E E, Jaksche H
Adv Tech Stand Neurosurg. 1984;11:169-207. doi: 10.1007/978-3-7091-7015-1_6.
CSF fistulas are a major complication of head injury but also occur spontaneously or symptomatically in connection with tumours of the skull base, empty sella syndrome, ethmoidal encephalomyelocele, intracranial hypertension or postoperatively in connection with operations on skull base tumours or ENT operations. Their main risk is the possibility of meningitis. The main clinical symptom is CSF leakage from the nose, but meningitis may be the first manifestation. Isotope cisternography and metrizamide CT cisternography are the most important methods for precise localization, sometimes also for verification of a suspected fistula. Most traumatic CSF fistulas of the frontal and ethmoidal region have to be treated operatively. The method of choice is the transfrontal approach and the closure of the fistula opening using a pedicled pericranial flap or fascia lata graft. Most sphenoidal fistulas have to be treated by packing the sphenoidal sinus with muscle. The treatment methods of the rare spontaneous and symptomatic CSF fistulas are also described. The results of operative treatment are satisfactory. About 6% recurrences, which as a rule can be cured by reoperation, and a mortality rate of about 1-3% seem to be an acceptable price for prevention of an otherwise unavoidable and oftenly deadly meningitis. Future efforts are necessary to improve the operative technique in order to reduce the incidence of anosmia. Our descriptions and advice are based not only on literature reports but also on our own experiences with a combined material of 237 cases operated on for rhinorrhea.
脑脊液瘘是头部损伤的主要并发症,但也可自发出现或与颅底肿瘤、空蝶鞍综合征、筛窦脑膨出、颅内高压相关,或在颅底肿瘤手术或耳鼻喉手术后出现症状。其主要风险是发生脑膜炎的可能性。主要临床症状是脑脊液鼻漏,但脑膜炎可能是首发表现。同位素脑池造影和甲泛葡胺CT脑池造影是精确定位的最重要方法,有时也用于证实可疑瘘管。大多数额部和筛窦区域的创伤性脑脊液瘘必须手术治疗。首选方法是经额入路,使用带蒂颅骨膜瓣或阔筋膜移植封闭瘘口。大多数蝶窦瘘必须通过用肌肉填充蝶窦来治疗。文中还描述了罕见的自发性和症状性脑脊液瘘的治疗方法。手术治疗结果令人满意。约6%的复发率(通常可通过再次手术治愈)和约1 - 3%的死亡率对于预防原本不可避免且往往致命的脑膜炎来说似乎是可以接受的代价。未来需要努力改进手术技术以降低嗅觉丧失的发生率。我们的描述和建议不仅基于文献报道,还基于我们对237例因鼻漏接受手术的综合病例材料的经验。