Makino T
Tokai J Exp Clin Med. 1984 Oct;9(4):297-305.
Fecal bile acids were analyzed by gas chromatography in 10 patients with colon cancer, 25 patients with colon polyp and 10 patients with peptic ulcer. On admission total bile acid excretion in patients with colon cancer was significantly higher than in patients with peptic ulcer (P less than 0.01). Also, concentration of cholic acid, chenodeoxycholic acid and primary bile acids in patients with colon cancer were significantly higher than those in patients with peptic ulcer (P less than 0.05, P less than 0.025) and in patients with colon polyp (P less than 0.005). Primary bile acids in patients with colon cancer significantly decreased under ward conditions after admission (P less than 0.05). Total bile acids in patients with colon cancer decreased after admission though there was no significant difference. It is of considerable interest that the fecal bile acid composition of colon cancer patients was different from that of colon polyp and peptic ulcer patients. Fecal bile acids may be involved in the pathogenesis of colon cancer.
采用气相色谱法对10例结肠癌患者、25例结肠息肉患者和10例消化性溃疡患者的粪便胆汁酸进行了分析。入院时，结肠癌患者的总胆汁酸排泄量显著高于消化性溃疡患者（P<0.01）。此外，结肠癌患者的胆酸、鹅去氧胆酸和初级胆汁酸浓度显著高于消化性溃疡患者（P<0.05，P<0.025）和结肠息肉患者（P<0.005）。入院后，在病房条件下，结肠癌患者的初级胆汁酸显著减少（P<0.05）。尽管差异不显著，但结肠癌患者入院后的总胆汁酸有所下降。值得关注的是，结肠癌患者的粪便胆汁酸组成与结肠息肉和消化性溃疡患者不同。粪便胆汁酸可能参与了结肠癌的发病机制。
