Rao S M, Hammeke T A
Brain Cogn. 1984 Jan;3(1):94-104. doi: 10.1016/0278-2626(84)90010-1.
Patients with chronic progressive MS (N = 38) were compared with an age and education matched medical control group (N = 19) on a visual discrimination task designed to evaluate hypothesis testing and focusing behavior. Thirty-three MS patients (85%) and all control patients were able to formulate and use hypotheses, but MS patients were less likely to employ strategies leading to a correct solution. Furthermore, MS patients were more likely to perseverate with one strategy despite negative verbal feedback. Five MS patients were unable to formulate hypotheses. These findings suggest that MS patients have impaired cognitive functioning in addition to previously reported problems with memory.
将患有慢性进行性多发性硬化症的患者（N = 38）与年龄和教育程度相匹配的医学对照组（N = 19）进行比较，后者参与了一项旨在评估假设检验和聚焦行为的视觉辨别任务。33名多发性硬化症患者（85%）和所有对照患者都能够形成并运用假设，但多发性硬化症患者采用能得出正确解决方案的策略的可能性较小。此外，尽管有负面的言语反馈，多发性硬化症患者更有可能坚持使用一种策略。5名多发性硬化症患者无法形成假设。这些发现表明，除了先前报道的记忆问题外，多发性硬化症患者还存在认知功能受损的情况。
