Matsumiya T, Sawa A, Oka T
Tokai J Exp Clin Med. 1983 Jul;8(3):257-63.
The effects of neuroleptics (droperidol and diazepam) were studied on the neural excitation by ketamine hydrochloride by means of the c-fiber reflex, in the spinal cat and the intact cat. Results can be summarized as follows: 1) Ketamine hydrochloride 125-500 micrograms/Kg i.v. facilitated the neural activity on the c-fiber reflex of the intact cat, but it depressed that of the spinal cat. 2) Droperidol 50-250 micrograms/Kg i.v. and diazepam 50-250 micrograms/Kg i.v. did not influence the neural activity on the c-fiber reflex of the intact cat, but it depressed that of the spinal cat. 3) Droperidol 125 micrograms/Kg i.v. followed by ketamine hydrochloride 125 micrograms/Kg i.v. facilitated the neural activity of the intact cat c-fiber reflex. 4) Diazepam 50 micrograms/Kg i.v. followed by ketamine hydrochloride 250 micrograms/Kg i.v. did not influence the neural activity of the intact cat c-fiber reflex. These data suggested that the neural excitation of ketamine hydrochloride was depressed by diazepam and that a small dose of droperidol did not depress the neural excitation of the intact cat.
在脊髓猫和完整猫身上，通过C纤维反射研究了神经阻滞剂（氟哌利多和地西泮）对氯胺酮所致神经兴奋的影响。结果总结如下：1）静脉注射125 - 500微克/千克的氯胺酮可促进完整猫C纤维反射的神经活动，但抑制脊髓猫的C纤维反射神经活动。2）静脉注射50 - 250微克/千克的氟哌利多和50 - 250微克/千克的地西泮对完整猫C纤维反射的神经活动无影响，但抑制脊髓猫的C纤维反射神经活动。3）静脉注射125微克/千克的氟哌利多后再静脉注射125微克/千克的氯胺酮可促进完整猫C纤维反射的神经活动。4）静脉注射50微克/千克的地西泮后再静脉注射250微克/千克的氯胺酮对完整猫C纤维反射的神经活动无影响。这些数据表明，地西泮可抑制氯胺酮的神经兴奋作用，小剂量氟哌利多不会抑制完整猫的神经兴奋。
