Kletzel M, Jaffe N
Cancer. 1981 Jan 15;47(2):245-7. doi: 10.1002/1097-0142(19810115)47:2<245::aid-cncr2820470207>3.0.co;2-q.
Intra-arterial Cis-diammine dichloroplatinum (II) administered to five patients produced systemic and sustained hypertension in four of them. This finding persisted for six months despite discontinuation of the drug. This complication has not been observed in patients receiving the drug by the intravenous route. Possible etiologic factors are discussed.
对五名患者进行动脉内顺二氯二氨铂(II)给药,其中四名患者出现了全身性和持续性高血压。尽管停药,但这一发现持续了六个月。接受静脉途径给药的患者未观察到这种并发症。文中讨论了可能的病因。