• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

视神经脊髓炎谱系疾病:脑脊液中抗胶质纤维酸性蛋白抗体

Devic's syndrome: antibody to glial fibrillary acidic protein in cerebrospinal fluid.

作者信息

Chou C H, Chou F C, Tourtellotte W W, Kibler R F

出版信息

Neurology. 1984 Jan;34(1):86-8. doi: 10.1212/wnl.34.1.86.

DOI:10.1212/wnl.34.1.86
PMID:6537858
Abstract

The cerebrospinal fluid of a patient with Devic's syndrome contained antiglial fibrillary acidic protein antibody. The serum level of antibody was less than that in cerebrospinal fluid, and the antibody was probably synthesized within the central nervous system. Similar antibody was not found in another patient with Devic's syndrome or in patients with multiple sclerosis. The role of the antibody in the patient's illness is uncertain, but is one of the few instances in which antibody against a specific brain antigen has been described in human demyelinating disease.

摘要

视神经脊髓炎患者的脑脊液中含有抗胶质纤维酸性蛋白抗体。抗体的血清水平低于脑脊液中的水平,且该抗体可能是在中枢神经系统内合成的。在另一例视神经脊髓炎患者或多发性硬化症患者中未发现类似抗体。该抗体在患者疾病中的作用尚不确定,但这是人类脱髓鞘疾病中为数不多的描述针对特定脑抗原的抗体的实例之一。

相似文献

1
Devic's syndrome: antibody to glial fibrillary acidic protein in cerebrospinal fluid.视神经脊髓炎谱系疾病:脑脊液中抗胶质纤维酸性蛋白抗体
Neurology. 1984 Jan;34(1):86-8. doi: 10.1212/wnl.34.1.86.
2
Cerebrospinal fluid and neuropathological study in Devic's syndrome. Evidence of intrathecal immune activation.
J Neurol Sci. 1987 Dec;82(1-3):281-90. doi: 10.1016/0022-510x(87)90024-4.
3
Cerebrospinal fluid proteins in neurology.
Int Rev Neurobiol. 1984;25:95-138. doi: 10.1016/s0074-7742(08)60678-9.
4
Serum antibodies against central nervous system proteins in human demyelinating disease.人类脱髓鞘疾病中针对中枢神经系统蛋白的血清抗体。
Clin Exp Immunol. 1985 Feb;59(2):383-90.
5
Search for antibodies to galactocerebroside in the serum and cerebrospinal fluid in human demyelinating disorders.在人类脱髓鞘疾病患者的血清和脑脊液中寻找半乳糖脑苷脂抗体。
Ann Neurol. 1987 Sep;22(3):381-3. doi: 10.1002/ana.410220316.
6
Astroprotein (GFAP) levels in cerebrospinal fluid of stroke patients.中风患者脑脊液中的星形胶质细胞蛋白(GFAP)水平。
Neurol Med Chir (Tokyo). 1984 Jan;24(1):13-8. doi: 10.2176/nmc.24.13.
7
Monoclonal antibodies to intermediate filament proteins of human cells: unique and cross-reacting antibodies.针对人类细胞中间丝蛋白的单克隆抗体:独特抗体与交叉反应抗体
J Cell Biol. 1982 Nov;95(2 Pt 1):414-24. doi: 10.1083/jcb.95.2.414.
8
Protein biomarkers for multiple sclerosis: semi-quantitative analysis of cerebrospinal fluid candidate protein biomarkers in different forms of multiple sclerosis.多发性硬化症的蛋白质生物标志物:不同形式多发性硬化症脑脊液候选蛋白生物标志物的半定量分析。
Mult Scler. 2012 Aug;18(8):1081-91. doi: 10.1177/1352458511433303. Epub 2012 Jan 17.
9
Blood and cerebrospinal fluid anomalies in brain ageing and Alzheimer's disease.脑老化和阿尔茨海默病中的血液和脑脊液异常
Gerontology. 1987;33(3-4):193-6. doi: 10.1159/000212875.
10
Antibodies reactive with intermediate filament proteins: new tools for the pathologist.
Ariz Med. 1984 Mar;41(3):177-9.

引用本文的文献

1
Successful treatment of a woman with relapsing neuromyelitis optica by interferon beta.成功用干扰素β治疗复发型视神经脊髓炎女性患者。
Neurol Sci. 2012 Aug;33(4):911-3. doi: 10.1007/s10072-011-0849-0. Epub 2011 Nov 27.
2
Anti-CNS antibodies in neurological and psychiatric disorders.神经和精神疾病中的抗中枢神经系统抗体。
J Neurol Neurosurg Psychiatry. 1987 Nov;50(11):1514-21. doi: 10.1136/jnnp.50.11.1514.