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A balance study of 14C-labelled 3H-imidazo[4,5-f]quinolin-2-amines (IQ and MeIQ) in rats.

作者信息

Sjödin P, Jägerstad M

出版信息

Food Chem Toxicol. 1984 Mar;22(3):207-10. doi: 10.1016/0278-6915(84)90128-5.

DOI:10.1016/0278-6915(84)90128-5
PMID:6538539
Abstract

The absorption and excretion of 14C-labelled 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) were studied in rats of both sexes. The excretion was rapid and within 24 hr more than 90% of the radioactivity had left the rats. After 72 hr the faecal excretion of both compounds was approximately 45-65% and the corresponding excretion via the urine amounted to 37-49%. Only 1-2% was left in the carcasses and less than 0.2% was found in the expired air. About 70% of the IQ and 80% of the MeIQ was found in the bile fluid in a separate 24-hr study. The two compounds had different biliary excretion patterns and the mutagenicity of the bile correlated closely with the excretion of radioactivity.

摘要

相似文献

1
A balance study of 14C-labelled 3H-imidazo[4,5-f]quinolin-2-amines (IQ and MeIQ) in rats.
Food Chem Toxicol. 1984 Mar;22(3):207-10. doi: 10.1016/0278-6915(84)90128-5.
2
Metabolism of 2-amino-3-methylimidazo[4,5-f]quinoline in the male rat.2-氨基-3-甲基咪唑并[4,5-f]喹啉在雄性大鼠体内的代谢
Food Chem Toxicol. 1989 Jun;27(6):369-76. doi: 10.1016/0278-6915(89)90142-7.
3
Autoradiographic distribution of 14C-labeled 3H-imidazo[4,5-f]quinoline-2-amines in mice.14C标记的3H-咪唑并[4,5-f]喹啉-2-胺在小鼠体内的放射自显影分布
Cancer Res. 1985 Mar;45(3):1351-6.
4
Genotoxic activity of the N-acetylated metabolites of the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ).食品诱变剂2-氨基-3-甲基咪唑[4,5-f]喹啉（IQ）和2-氨基-3,4-二甲基咪唑[4,5-f]喹啉（MeIQ）的N-乙酰化代谢产物的遗传毒性活性。
Mutagenesis. 1988 Jul;3(4):303-9. doi: 10.1093/mutage/3.4.303.
5
Characterisation of metabolites of the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline formed after incubation with isolated rat liver cells.食物诱变剂2-氨基-3-甲基咪唑并[4,5-f]喹啉和2-氨基-3,4-二甲基咪唑并[4,5-f]喹啉与分离的大鼠肝细胞孵育后形成的代谢产物的表征
Chem Biol Interact. 1989;72(1-2):125-42. doi: 10.1016/0009-2797(89)90023-9.
6
Modulation of the mutagenic effects of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) in bacteria with rat-liver 9000 x g supernatant or monolayers of rat hepatocytes as an activation system.以大鼠肝脏9000×g上清液或大鼠肝细胞单层作为激活系统，对细菌中2-氨基-3-甲基咪唑并[4,5-f]喹啉（IQ）和2-氨基-3,4-二甲基咪唑并[4,5-f]喹啉（MeIQ）的诱变作用进行调节。
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7
Disposition and metabolism of the food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in rats.食物诱变剂2-氨基-3,8-二甲基咪唑并[4,5-f]喹喔啉（MeIQx）在大鼠体内的处置与代谢
Carcinogenesis. 1989 Jul;10(7):1269-75. doi: 10.1093/carcin/10.7.1269.
8
Fluorometric detection of 2-amino-3-methylimidazo[4,5-f]quinoline, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline and their N-acetylated metabolites excreted by the rat.大鼠排泄的2-氨基-3-甲基咪唑并[4,5-f]喹啉、2-氨基-3,4-二甲基咪唑并[4,5-f]喹啉及其N-乙酰化代谢产物的荧光检测
Carcinogenesis. 1987 Sep;8(9):1277-80. doi: 10.1093/carcin/8.9.1277.
9
Studies on the mechanism of cancer protection by wheat bran: effects on the absorption, metabolism and excretion of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).麦麸防癌机制的研究：对食物致癌物2-氨基-3-甲基咪唑[4,5-f]喹啉（IQ）吸收、代谢及排泄的影响。
Carcinogenesis. 1999 Dec;20(12):2253-60. doi: 10.1093/carcin/20.12.2253.
10
Activation of the food mutagens IQ and MeIQ by hepatic S9 fractions derived from various species.
Mutat Res. 1985 Oct;144(2):59-62. doi: 10.1016/0165-7992(85)90001-6.

引用本文的文献

1
N-Demethylation is a major route of 2-amino-3-methylimidazo[4,5-f]quinoline metabolism in mouse.N-去甲基化是2-氨基-3-甲基咪唑并[4,5-f]喹啉在小鼠体内代谢的主要途径。
Drug Metab Dispos. 2008 Jun;36(6):1143-52. doi: 10.1124/dmd.107.019166. Epub 2008 Mar 20.
2
Dietary modulation of DNA adduct formation of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the male Fischer 344 rat.膳食对雄性费希尔344大鼠食物诱变剂2-氨基-3-甲基咪唑并[4,5-f]喹啉DNA加合物形成的调节作用。
Environ Health Perspect. 1994 Oct;102 Suppl 6(Suppl 6):57-60. doi: 10.1289/ehp.94102s657.
3
Comparison of XAD-2 column and blue cotton batch techniques for isolation of metabolites of 2-amino-3-methylimidazo[4,5-f]quinoline.
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Jpn J Cancer Res. 1988 Jan;79(1):42-8. doi: 10.1111/j.1349-7006.1988.tb00009.x.