111In标记的二乙三胺五乙酸（DTPA）和三亚乙基四胺六乙酸（TTHA）单克隆抗体缀合物在绒毛膜癌异种移植模型中的比较分布研究
A comparative distribution study of 111In-labeled DTPA and TTHA monoclonal antibody conjugates in a choriocarcinoma xenograft model.
作者信息
Buckley R G, Barnett P, Searle F, Pedley R, Boden J A
出版信息
Eur J Nucl Med. 1986;12(8):394-6. doi: 10.1007/BF00252197.
Conjugates of the chelating agents DTPA and TTHA with a monoclonal anti-HCG were prepared. The tissue distribution of the 111In-labeled conjugates and also 111In-citrate was studied in mice bearing human choriocarcinoma xenografts. The antibody conjugates both gave high liver and spleen radionuclide accumulation. Elevated femur levels were observed for the TTHA conjugate and 111In-citrate. Generally the DTPA conjugate showed the highest tumor/tissue ratios, although its tumor/blood ratio was lower than the other two materials. The results infer that the DTPA conjugate has the greatest utility as an imaging agent but that it would require a background subtraction technique.
制备了螯合剂二乙三胺五乙酸（DTPA）和三亚乙基四胺六乙酸（TTHA）与单克隆抗人绒毛膜促性腺激素（anti-HCG）的偶联物。研究了用铟-111（¹¹¹In）标记的偶联物以及¹¹¹In-柠檬酸盐在荷人绒毛膜癌异种移植瘤小鼠体内的组织分布。抗体偶联物均使肝脏和脾脏有较高的放射性核素蓄积。观察到TTHA偶联物和¹¹¹In-柠檬酸盐在股骨中的水平升高。一般来说，DTPA偶联物显示出最高的肿瘤/组织比值，尽管其肿瘤/血液比值低于其他两种物质。结果表明，DTPA偶联物作为一种成像剂具有最大的效用，但它需要一种背景扣除技术。
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