Scatton B, Fage D
Eur J Pharmacol. 1984 Feb 10;98(1):1-7. doi: 10.1016/0014-2999(84)90102-x.
The influence of hypophysectomy on biochemical indices of striatal dopamine target cell supersensitivity induced by prolonged haloperidol treatment was investigated in the rat. Hypophysectomy itself did not modify dihydroxyphenylacetic acid (DOPAC) levels but slightly enhanced acetylcholine concentrations in the striatum. Hypophysectomy failed to affect the ability of haloperidol, apomorphine and pergolide to alter these biochemical parameters after acute administration. Prolonged administration of haloperidol (by means of osmotic minipumps delivering 2.5 micrograms/h) for 14 days caused a decrease in DOPAC and an increase in acetylcholine levels in the striatum during withdrawal; these effects were of a similar magnitude in sham-operated and hypophysectomized rats. Moreover, there was a similar degree of tolerance to the elevation of DOPAC and to the diminution of acetylcholine concentrations in striatum in response to challenge with haloperidol during withdrawal in sham-operated and hypophysectomized animals. Finally, a similar supersensitive biochemical response to pergolide (decrease in DOPAC and increase in acetylcholine levels) was observed in both hypophysectomized and sham-operated animals after prolonged haloperidol treatment. These data suggest that hypophyseal factors do not affect the development of striatal dopamine target cell supersensitivity caused by prolonged haloperidol treatment.
在大鼠中研究了垂体切除对长期服用氟哌啶醇诱导的纹状体多巴胺靶细胞超敏反应生化指标的影响。垂体切除本身并未改变二羟基苯乙酸（DOPAC）水平，但略微提高了纹状体中的乙酰胆碱浓度。垂体切除未能影响氟哌啶醇、阿扑吗啡和培高利特急性给药后改变这些生化参数的能力。长期（通过渗透微型泵以2.5微克/小时的速度给药）给予氟哌啶醇14天，在撤药期间导致纹状体中DOPAC减少和乙酰胆碱水平升高；在假手术和垂体切除的大鼠中，这些效应的程度相似。此外，在假手术和垂体切除的动物撤药期间，对氟哌啶醇激发后纹状体中DOPAC升高和乙酰胆碱浓度降低的耐受程度相似。最后，在长期服用氟哌啶醇后，垂体切除和假手术的动物中均观察到对培高利特的类似超敏生化反应（DOPAC降低和乙酰胆碱水平升高）。这些数据表明垂体因素不影响长期服用氟哌啶醇引起的纹状体多巴胺靶细胞超敏反应的发展。
