Leaf R C, Wnek D J, Lamon S
Pharmacol Biochem Behav. 1984 Feb;20(2):311-3. doi: 10.1016/0091-3057(84)90260-0.
Oxazepam (2.5-80 mg/kg) induced significant mouse killing among large samples (N = 100/dose) of Holtzman strain albino rats. Meprobamate (2.5-80 mg/kg) and Chlorpromazine (0.5-4 mg/kg) did not induce killing. Despite its lesser tendency to induce aggression in humans, Oxazepam is as potent as Chlordiazepoxide for inducing killing by rats. Induction of mouse killing by rats appears to the predict clinical potency rather than the aggressive side-effects of anxiolytic benzodiazepines.
奥沙西泮（2.5 - 80毫克/千克）在大量样本（每个剂量组N = 100）的霍尔茨曼品系白化大鼠中诱发了显著的杀鼠现象。甲丙氨酯（2.5 - 80毫克/千克）和氯丙嗪（0.5 - 4毫克/千克）未诱发杀鼠现象。尽管奥沙西泮在人类中诱发攻击行为的倾向较小，但它在诱发大鼠杀鼠方面与氯氮卓的效力相当。大鼠杀鼠现象的诱发似乎可预测临床效力，而非抗焦虑苯二氮䓬类药物的攻击副作用。
