Engelmann U, Krug J, Sonntag W, Jacobi G H
Urol Int. 1984;39(2):73-9. doi: 10.1159/000280949.
The influence of a single dose cisplatin on wound healing of enterostomies in rats was investigated by measurement of the wound-breaking strength, microangiographically and histologically. Cisplatin (5 mg/kg body weight) was given on day-1 or day-5 preoperatively. Cisplatin led to a significant reduction of the wound-breaking strength, mostly marked on day +14 after operation. The reasons are: a reduced induction of connective tissue proliferation; an inhibition of proliferation of fibroblasts and endothelial cells, and a retardation of vessel proliferation.
通过测量伤口抗张强度、微血管造影和组织学方法，研究了单剂量顺铂对大鼠肠造口术伤口愈合的影响。在术前第1天或第5天给予顺铂（5mg/kg体重）。顺铂导致伤口抗张强度显著降低，主要在术后第14天表现明显。原因如下：结缔组织增殖诱导减少；成纤维细胞和内皮细胞增殖受到抑制，以及血管增殖延迟。
