Engelmann U, Grimm K, Grönniger J, Bürger R, Jacobi G H
Eur Urol. 1983;9(1):45-9. doi: 10.1159/000474042.
The influence of cis-platinum on the wound healing of bowel anastomoses was studied in 104 male Sprague-Dawley rats. After a single preoperative doses of 5 mg/kg body weight, the wound-breaking strength (WBS) was tested with a material tester on the 4th, 7th, 14th and 28th day postoperatively. The WBS was significantly lower in treated animals as compared to the untreated controls. The reasons for this are discussed in comparison with other cytotoxic agents. Before cis-platinum can be used as adjuvant chemotherapy to cystectomy, which is frequently combined with an ileum or colon conduit procedure, further investigations on the operative side effects of cis-platinum on bowel anastomoses are necessary.
在104只雄性斯普拉格-道利大鼠中研究了顺铂对肠吻合口愈合的影响。术前单次给予5mg/kg体重剂量后，在术后第4、7、14和28天用材料测试仪测试伤口断裂强度（WBS）。与未治疗的对照组相比，治疗组动物的WBS明显较低。与其他细胞毒性药物相比，讨论了其原因。在顺铂可作为膀胱切除术辅助化疗药物（膀胱切除术常与回肠或结肠造口术联合进行）之前，有必要进一步研究顺铂对肠吻合口的手术副作用。
