心房利钠因子肽成分的分离与序列测定
Isolation and sequence determination of peptide components of atrial natriuretic factor.
作者信息
Napier M A, Dewey R S, Albers-Schönberg G, Bennett C D, Rodkey J A, Marsh E A, Whinnery M, Seymour A A, Blaine E H
出版信息
Biochem Biophys Res Commun. 1984 May 16;120(3):981-8. doi: 10.1016/s0006-291x(84)80203-x.
The independent isolation and sequence determination in our laboratories of three closely related Atrial Natriuretic Factor peptides from rat atria confirm the sequences of ANF peptides reported by Seidah et al and synthesized by Nutt et al [Proc. Natl. Acad. Sci., (1984) in press] and contain the sequences reported by Flynn et al [Biochem. Biophys. Res. Commun. (1983) 117: 859-865] and by Currie et al [Science (1984) 223: 67-69]. In addition, we provide proof for a C-terminal tyrosine rather than tyrosine amide in our isolated peptides.
我们实验室从大鼠心房中独立分离并测定了三种密切相关的心房利钠因子肽的序列，证实了Seidah等人报道并由Nutt等人合成的ANF肽序列[《美国国家科学院院刊》，（1984年）待发表]，并包含Flynn等人[《生物化学与生物物理研究通讯》（1983年）117：859 - 865]以及Currie等人[《科学》（1984年）223：67 - 69]报道的序列。此外，我们还证明了我们分离出的肽的C末端是酪氨酸而非酪氨酸酰胺。
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