一种具有强效利尿和排钠特性的心房肽的氨基酸序列。
The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties.
作者信息
Flynn T G, de Bold M L, de Bold A J
出版信息
Biochem Biophys Res Commun. 1983 Dec 28;117(3):859-65. doi: 10.1016/0006-291x(83)91675-3.
A 28 amino acid peptide with diuretic and natriuretic activity has been purified from rat atrial muscle. The primary structure of this atrial peptide is H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly- (sequence in text) Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-(Arg)-Tyr-OH. The biological activity of this peptide is identical to that of atrial natriuretic factor and cardionatrin I isolated from rat atria.
一种具有利尿和利钠活性的28个氨基酸的肽已从大鼠心房肌中纯化出来。这种心房肽的一级结构为H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-（文本中的序列）Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-(Arg)-Tyr-OH。这种肽的生物活性与从大鼠心房中分离出的心房利钠因子和心钠素I相同。
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