Quinn N, Parkes J D, Marsden C D
Neurology. 1984 Sep;34(9):1131-6. doi: 10.1212/wnl.34.9.1131.
In 10 parkinsonian patients with severe, chaotic clinical response fluctuations, oral levodopa treatment was replaced by continuous intravenous infusion of levodopa (with orally administered benserazide). Four patients were also given levodopa infusions in addition to their usual oral treatment. All patients remained continuously mobile and ambulant during the infusions. Side effects were minimal, except in two patients with diphasic dyskinesias whose abnormal movements were consistently suppressed by a further increase in the rate of levodopa administration, only to return after an interval. If a soluble nonacidic dopamine replacement drug can be developed for continuous subcutaneous infusion, "brittle" parkinsonians may be chronically controlled by portable, minipump technology.
在10例临床反应严重且波动紊乱的帕金森病患者中，口服左旋多巴治疗被左旋多巴持续静脉输注（同时口服苄丝肼）所取代。4例患者在常规口服治疗基础上还接受了左旋多巴输注。所有患者在输注过程中均能持续活动且可走动。副作用轻微，仅有2例患有双相运动障碍的患者除外，其异常运动在左旋多巴给药速率进一步增加后持续受到抑制，但间隔一段时间后又会复发。如果能够研发出一种可用于持续皮下输注的可溶性非酸性多巴胺替代药物，“脆性”帕金森病患者或许可以通过便携式微型泵技术得到长期控制。
