Peppe A, De Angelis D, Tolli V S, Rizzo P A, Scoppetta C
Istituto di Clinica delle Malattie Nervose e Mentali, Università, La Sapienza, Roma.
Riv Neurol. 1991 Sep-Oct;61(5):197-200.
Most of Parkinson's disease patients treated with Levodopa develop the Long Treatment Levodopa Syndrome. Many authors showed a correlation between clinical features and plasma level of Levodopa. In our study, five parkinsonian patients with severe clinical response fluctuations, oral levodopa treatment was replaced by repeated continuous infusions of Levodopa (with oral carbidopa). Our results confirm that repeated intravenous infusion are very effective in PD patients with LTS.
大多数接受左旋多巴治疗的帕金森病患者会出现长期左旋多巴治疗综合征。许多作者表明临床特征与左旋多巴血浆水平之间存在相关性。在我们的研究中,5例帕金森病患者临床反应波动严重,口服左旋多巴治疗被左旋多巴(联合口服卡比多巴)的重复持续输注所取代。我们的结果证实,重复静脉输注对患有长期左旋多巴治疗综合征的帕金森病患者非常有效。