Mattson R H, Cramer J A, Caldwell B V, Siconolfi B C
Neurology. 1984 Sep;34(9):1255-8. doi: 10.1212/wnl.34.9.1255.
Medroxyprogesterone acetate (MPA), a synthetic progesterone, was added to the antiepileptic drug regimen of 14 women who had uncontrolled seizures. Of the 11 women who developed amenorrhea, 7 reported fewer seizures during MPA therapy. Overall reductions in seizure frequency averaged 30% (n = 11), declining from a baseline 8.3 +/- 5.8 seizures per month to 5.1 +/- 4.1 seizures per month (p = 0.02). No serious side effects were encountered, but spotting was common. These preliminary data suggest further evaluation of MPA for catamenial seizures.
醋酸甲羟孕酮（MPA）是一种合成孕激素，被添加到14名癫痫发作未得到控制的女性的抗癫痫药物治疗方案中。在出现闭经的11名女性中，有7名报告在MPA治疗期间癫痫发作次数减少。癫痫发作频率总体平均降低了30%（n = 11），从基线时每月8.3±5.8次发作降至每月5.1±4.1次发作（p = 0.02）。未出现严重副作用，但点滴出血很常见。这些初步数据表明需对MPA用于经期性癫痫发作进行进一步评估。
