Baly D L, Golub M S, Gershwin M E, Hurley L S
Am J Clin Nutr. 1984 Aug;40(2):199-207. doi: 10.1093/ajcn/40.2.199.
The relationship between dietary zinc, vitamin A, and retinol-binding protein (RBP) was studied in pregnant rhesus monkeys. Beginning on day 0 of gestation, monkeys were divided into three groups; 1) eight ad libitum-fed controls (AL) fed a diet containing 100 micrograms/g zinc, 2) 15 zinc-deprived (ZD) fed a diet containing 4 micrograms/g zinc, 3) 11 pair-fed controls (PF) fed the 100 micrograms/g control diet in amounts equal to those consumed by ZD animals. ZD monkeys had lower plasma zinc levels than did the AL and PF groups at day 135 of gestation, and at 1 and 3 months gestation. A positive correlation between plasma vitamin A and plasma zinc was observed (r = 0.5150, p less than 0.05) and between RBP and zinc (r = 0.883, p less than 0.001) in the ZD group at day 135 of pregnancy. By 3 months postpartum, plasma zinc levels increased in all groups; a positive correlation between zinc and vitamin A was observed in the ZD group (r = 0.5162, p less than 0.05) and in the PF group (r = 0.6353, p less than 0.05); however, no correlation between zinc and RBP was observed. In ZD monkeys, the ratio of RBP to vitamin A was higher (p less than 0.05) than in controls at day 135 of pregnancy. Polynomial regression of the interaction between plasma vitamin A and zinc, and the RBP/vitamin A and zinc, indicated a curvilinear relationship between plasma zinc and these two parameters.(ABSTRACT TRUNCATED AT 250 WORDS)
在怀孕的恒河猴中研究了膳食锌、维生素A和视黄醇结合蛋白（RBP）之间的关系。从妊娠第0天开始，将猴子分为三组：1）八只自由采食的对照组（AL），喂食含100微克/克锌的日粮；2）15只锌缺乏组（ZD），喂食含4微克/克锌的日粮；3）11只配对喂食对照组（PF），喂食100微克/克的对照日粮，其摄入量与ZD组动物的摄入量相等。在妊娠第135天以及妊娠1个月和3个月时，ZD组猴子的血浆锌水平低于AL组和PF组。在妊娠第135天，ZD组血浆维生素A与血浆锌之间呈正相关（r = 0.5150，p < 0.05），RBP与锌之间也呈正相关（r = 0.883，p < 0.001）。到产后3个月时，所有组的血浆锌水平均升高；ZD组（r = 0.5162，p < 0.05）和PF组（r = 0.6353，p < 0.05）中锌与维生素A之间呈正相关；然而，未观察到锌与RBP之间的相关性。在妊娠第135天，ZD组猴子中RBP与维生素A的比值高于对照组（p < 0.05）。血浆维生素A与锌之间以及RBP/维生素A与锌之间相互作用的多项式回归表明，血浆锌与这两个参数之间呈曲线关系。（摘要截短至250字）
