Keen C L, Golub M S, Gershwin M E, Lönnerdal B, Hurley L S
Department of Nutrition, California Primate Research Center, Davis.
Am J Clin Nutr. 1988 Jun;47(6):1041-5. doi: 10.1093/ajcn/47.6.1041.
Studies of marginal zinc deficiency in rhesus monkeys have demonstrated that plasma Zn levels are often a poor indication of Zn status. To better assess the Zn status of these animals, we examined their liver concentration of Zn as well as of other minerals, metallothionein (MT), and superoxide dismutase (SOD). Liver-wedge biopsies were obtained from adult rhesus monkeys fed for 15 mo, either a control (100 micrograms Zn/g) or a marginally Zn deficient diet (4 micrograms/g; ZD). Liver Zn and MT concentrations were lower in ZD monkeys than in controls whereas iron concentration was higher in ZD monkeys than in controls. Liver copper, manganese, and magnesium concentrations and activities of CuZnSOD and MnSOD were similar in the two groups. Data from the groups were pooled for regression analysis. Measurement of liver Zn and MT concentrations are useful in the assessment of the effects of long-term Zn deprivation in primates.
对恒河猴边缘性锌缺乏的研究表明，血浆锌水平往往不能很好地反映锌的状态。为了更好地评估这些动物的锌状态，我们检测了它们肝脏中锌以及其他矿物质、金属硫蛋白（MT）和超氧化物歧化酶（SOD）的含量。从成年恒河猴身上获取肝楔形活检组织，这些猴子被喂食15个月，分别是对照饮食（每克含100微克锌）或边缘性锌缺乏饮食（每克含4微克锌；ZD）。ZD组猴子肝脏中的锌和MT含量低于对照组，而ZD组猴子肝脏中的铁含量高于对照组。两组的肝脏铜、锰、镁含量以及铜锌超氧化物歧化酶（CuZnSOD）和锰超氧化物歧化酶（MnSOD）的活性相似。将两组数据合并进行回归分析。测量肝脏锌和MT含量有助于评估长期锌缺乏对灵长类动物的影响。
