某些氨基酸对皮肤癣菌的抗真菌活性。

Antimycotic activity of some amino acids against dermatophytes.

作者信息

Pandey D K, Chandra H, Tripathi N N, Dixit S N

出版信息

Arzneimittelforschung. 1984;34(5):554-6.

Abstract

20 amino acids were assayed at 1% concentration for their toxicity against the mycelial growth of two dermatophytes viz., Microsporum gypseum and Trichophyton mentagrophytes. L-Cysteine hydrochloride exhibited absolute toxicity against both the test pathogens while DL-aspartic acid was found active against Microsporum gypseum only. The minimum inhibitory concentrations of L-cysteine hydrochloride was found to be 0.5 and 0.4% against M. gypseum and T. mentagrophytes, respectively, at which it showed mycostatic nature. However, the amino acid exhibited mycocidal activity at 0.9 and 0.8% against M. gypseum T. mentagrophytes, respectively. The spectrum of L-cysteine hydrochloride was studied at 1 and 0.5% concentrations against 24 human and animal pathogenic fungi and it was found to possess broad range of activity. The mycotoxicity of amino acid remained unaltered at high temperature, on autoclaving and against high inoculum density. Besides, it showed stronger activity in comparison to four antimycotic drugs viz., griseofulvin, 5-bromosalicyl-4-chloranilidine, acidum undecylenicum and nystatin.

摘要

对20种氨基酸在1%浓度下针对两种皮肤癣菌（即石膏样小孢子菌和须癣毛癣菌）的菌丝生长毒性进行了测定。盐酸L-半胱氨酸对两种受试病原体均表现出绝对毒性，而DL-天冬氨酸仅对石膏样小孢子菌有活性。发现盐酸L-半胱氨酸对石膏样小孢子菌和须癣毛癣菌的最低抑菌浓度分别为0.5%和0.4%，在此浓度下它表现出抑菌特性。然而，该氨基酸对石膏样小孢子菌和须癣毛癣菌的杀真菌活性分别在0.9%和0.8%时出现。研究了盐酸L-半胱氨酸在1%和0.5%浓度下对24种人和动物致病真菌的抗菌谱，发现其具有广泛的活性。该氨基酸的真菌毒性在高温、高压灭菌和高接种密度下保持不变。此外，与四种抗真菌药物（即灰黄霉素、5-溴水杨基-4-氯苯胺、十一烯酸和制霉菌素）相比，它表现出更强的活性。