Macura A B, Filip E, Pawlik B
Zakład Mykologii Instytutu Mikrobiologii AM w Krakowie.
Med Dosw Mikrobiol. 1993;45(2):253-7.
A serial dilution and a disc method were used for evaluation of susceptibility of 50 dermatophyte strains belonging to the species Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis and Epidermophyton floccosum. Following drugs were investigated: griseofulvin, pimaricin, clotrimoxazole, miconazole, ketoconazole, biphonazole and naftifin. Application of two methods of testing resulted in high convergence of determinations. Naftifin was most effective and pimaricin least active. Among imidazole drugs, relatively high activity against dermatophytes was exhibited by clotrimoxazole and ketoconazole. Strain of Trichophyton rubrum were more susceptible to antifungal drugs than strains of Trichophyton mentagrophytes.
采用系列稀释法和纸片法对50株红色毛癣菌、须癣毛癣菌、犬小孢子菌和絮状表皮癣菌进行药敏试验。检测的药物如下：灰黄霉素、匹马霉素、克霉唑、咪康唑、酮康唑、联苯苄唑和萘替芬。两种检测方法的应用导致检测结果高度一致。萘替芬最有效，匹马霉素活性最低。在咪唑类药物中，克霉唑和酮康唑对皮肤癣菌表现出相对较高的活性。红色毛癣菌菌株比须癣毛癣菌菌株对抗真菌药物更敏感。
