LeKim D, Betzing H
Arzneimittelforschung. 1984;34(5):557-9.
The rate and mechanism of incorporation of polyene phosphatidylcholine (PPC) and lysophosphatidylcholine into rat brain have been studied with double labelled substrates administered intravenously. It was found that both substances could be taken up into the brain with transfer velocities of the order: lysophosphatidylcholine much greater than phosphatidylcholine greater than glycerophosphocholine. Similarities between the 3H/14C ratios of the substrates and the brain phosphatidylcholine, together with retention of the label in the original acyl moieties, as demonstrated by phospholipase A2 hydrolysis, gave conclusive proof that both PPC and lysophosphatidylcholine are taken up intact into the brain.
通过静脉注射双标记底物，研究了多烯磷脂酰胆碱（PPC）和溶血磷脂酰胆碱掺入大鼠脑内的速率和机制。结果发现，两种物质均可被脑摄取，其转运速度顺序为：溶血磷脂酰胆碱远大于磷脂酰胆碱大于甘油磷酸胆碱。底物与脑磷脂酰胆碱的3H/14C比值相似，以及磷脂酶A2水解所证明的标记物保留在原始酰基部分，确凿地证明了PPC和溶血磷脂酰胆碱均完整地被脑摄取。
