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[遗传性高血压和正常动脉压动物心肌对压力损伤作用的比较评估]

[Comparative evaluation of the myocardial resistance of animals with hereditary hypertension and normal arterial pressure to the damaging action of stress].

作者信息

Katkova L S, Kozlov Iu P, Meerson F Z

出版信息

Nauchnye Doki Vyss Shkoly Biol Nauki. 1984(6):34-9.

PMID:6540603
Abstract

In normotensive WKY and August rats the 6-hour immobilized stress has been shown to result in decrease of heart muscle extensibility, in depression of developed tension and reduction of myocardial resistance to hypoxic and calcium contractures. This complex does not develope the post-stress disturbances of miocardial function in spontaneously hepertensive rats (SHR) which heart muscle is characterized by reduced adrenoreactivity. The heart adrenoreactivity is supposed to be one of the important factors determining its resistance to stress damage in animals of different strains.

摘要

在血压正常的WKY大鼠和奥古斯特大鼠中,6小时的固定应激已被证明会导致心肌伸展性降低、舒张期张力降低以及心肌对缺氧和钙挛缩的抵抗力降低。这种情况在自发性高血压大鼠(SHR)中不会引发应激后心肌功能障碍,其心肌的特点是肾上腺素反应性降低。心脏肾上腺素反应性被认为是决定不同品系动物心脏对应激损伤抵抗力的重要因素之一。

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